ea0008oc3 | Growth and Development | SFE2004
Brereton H
, Luther MJ
, Hauge-Evans AC
, Persaud SJ
, Jones PM
We have previously used insulin-secreting MIN6 cells configured into islet-like structures (pseudoislets) to demonstrate that homotypic interactions between beta-cells are essential for normal insulin secretory responses. We have now investigated whether homotypic interactions are important in secretion of other pancreatic hormones. Glucagon-secreting alpha-TC1 cells were cultured as adherent monolayers, or as pseudoislets grown on gelatin, and hormone release was measured in ...